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With these caveats in mind, the study nevertheless provides highly useful information. Furthermore, molecular detection of viral nucleic acid is not conclusive proof of active infection.
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Each of these factors suggests caution in generalizing the results of the findings. The molecular test was a developmental version of the FilmArray Respiratory Panel multiplex respiratory panel, and the performance characteristics of this test version were not provided. With participants being recruited from a university community, the study population was probably more educated and from a higher socioeconomic stratum than the general US population. In addition, the study was confined to a single community during a single year. The numbers of households and participants were relatively small. While the study has the significant strengths described above, it also has limitations. Illness episodes were defined as continuous periods of presence of symptoms, and virus episodes were defined as continuous periods of detection of the same virus. Each week was characterized with regard to occurrence of illness based on the symptom diary and presence or absence of respiratory viruses as measured by the molecular test. To the credit of the investigative team, diaries and specimens were available for analysis from 77% of episodes. Diaries also included information on absence from work or school and on medical visits. A total of 108 individuals in 26 households from the University of Utah campus community provided symptom diaries and self-collected anterior nasal swab samples weekly for 52 consecutive weeks. BIG-LoVE is one of a new generation of community-based studies that “flesh out” that framework by using molecular methods that are more sensitive than previous methods.īIG-LoVE resembles the classic studies by being community based, with specimens obtained from study participants on a regular basis, regardless of the presence or absence of symptoms, but the study stands out by virtue of the intensity of virologic and clinical surveillance undertaken. Those studies, which were based on viral culture and/or serology, established our current conceptual framework for the community epidemiology of viral respiratory tract infection. The study stands squarely in the tradition of the historic community-based studies of viral respiratory infection, including the Cleveland Family study, the Tecumseh study, and the New York and Seattle Virus Watches.
#Cid episode 1217 serial#
Based on serial molecular testing for respiratory viruses carried out on a defined population, BIG-LoVE provides a wealth of information about the relationship between respiratory symptoms and respiratory viral infection. In this issue of Clinical Infectious Diseases, Byington et al report on findings from the BIG-LoVE (Better Identification of Germs Longitudinal Viral Epidemiology) study. (See the Major Article by Byington et al on pages 1217–24.) Respiratory virus, asymptomatic illness, rhinovirus, bocavirus, coronavirus